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sildenafil citrate fluoxetine There are a number of discoveries for other applications of Sildenafil and most of them are not related to erectile dysfunction (ED) at all. For instance, this research from Bolnick, “Sildenafil Prevents Apoptosis of Human First-Trimester Trophoblast Cells Exposed to Oxidative Stress Possible Role for Nitric Oxide Activation of 3′, 5′-cyclic Guanosine Monophosphate Signaling”, the role of Sildenafil was studied in the survival of the human first-trimester trophoblast cells [5]. These cells thrive at low O2 levels but they terminate due to oxidative stress.

Recommended Doses and Duration of Therapy

  • sildenafil and fluoxetine The known recommended dosage for Sildenafil treatment can go as low as 25 mg to as high as 200 mg per intake, depending on the client’s medical history, underlying conditions, and dosage tolerance [8].
  • There is no indicated length or duration for Sildenafil treatment although there are not many contraindications to its long-term use, as it is generally safe to take even for chronic ED conditions.
  • sildenafil with fluoxetine It is recommended to follow the doctor’s instructions on the intake of the drug and never exceed one dose of Sildenafil for ED in a day. Its use is also limited to an as-needed basis and should not be taken almost daily [8].

How Sildenafil Functions

sildenafil + fluoxetine 60 mg As for Sildenafil’s mechanism of action in treating ED in patients, it is known to have a direct action in the PDE5. Following sexual stimulation, nitric oxide (NO) is released in the corpus cavernosum in the penis and encourages the release of cGMP (cyclic guanosine monophosphate) which stimulates relaxation of the smooth muscles which encourage blood flow to the penis, and vasoconstriction of veins which results into erection. Since PDE5 which degrade the cGMP mediating the erectile response, the erection continues uninhibited. This mechanism of Sildenafil continues in about 4 hours as it is the lifetime of the drug in the bloodstream.

Sildenafil Citrate Implied Effects

sildenafil fluoxetine Patients can expect the same erection-enhancing mechanism every time they are treated with Sildenafil since its effect is already established by research and scientific studies, there is no more question in the effectiveness of Sildenafil in the treatment of the dysfunction, even in the low dosages (25 mg and 50 mg) [1]. The patients treated with sildenafil can expect improved erections and the hardness even in 25 mg/50 mg dosage administrations [1].

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